EMDataResource Pseudotorsion Plot Beta Server
RNA adopts complex three-dimensional folding patterns and has key roles in many cellular functions. Many cryoEM-derived structures contain RNA, including ribosomal particles, spliceosomes, RNA viruses, and polymerase complexes, yet procedures for validation of RNA structures are not as well developed as those for proteins.
This prototype web-service for virtual torsion angle validation of RNA structures can be applied to structures determined using cryo-EM as well as other structural methods. Virtual torsion angle plots for nucleic acids are analogous to Ramachandran plots for proteins. The tool evaluates single structures, either by file upload (mmCIF or PDB format) or by entering a PDB id.
The research community has developed simplified ways to represent nucleic acid backbone conformation through use of virtual torsion angles1-3. A common scheme is to define two virtual torsion angles (pseudotorsions), eta (η) and theta (θ) for a nucleotide triplet. The measured (η,θ) pair defines the backbone conformation relative to central residue (i).
The server calculates three varieties of pseudotorsion angles, as shown in the image below. In all definitions, phosphate atom positions are used, but the alternate atom differs: it is either the C4' atom (η,θ), C1' atom (η',θ'), or base origin4,5 position (η",θ").
Virtual torsion angles of the RNA backbone (calculated using DSSR4) are compared against the statistical distribution of a benchmark set of high quality, non-redundant6 RNA structures determined by X-ray crystallography at ≤ 2.5 Å. Separate analyses are performed based on sugar-puckering type (of ~27,000 residues in the benchmark set, ~24,000 are C3'-endo-like, ~3,000 are C2'-endo-like). Output plots and and a downloadable (csv format) table identify probable conformational outliers for any given RNA-containing structure. For comparison, RNA Suiteness7,8 scores are also provided in the csv (for residue i, suiteness of the i-1, i dinucleotide is listed. Suiteness range is 0(poor)-1(excellent). Calculation performed using DSSR).
The 2D plots permit comparison of pseudotorsion pairs for the structure being evaluated (plotted points) against population statistics of the benchmark set (smoothed contours: bar at right indicates benchmark residue count range). Outliers are marked on the plots by red crosses with residue information available on mouse hover. Summary statistics are provided below each plot to indicate the number of residues evaluated and percent outliers. Note that pseudotorsion angles cannot be calculated for terminal residues or around breaks in the polymer chain, so these are excluded from evaluation.
This tool is designed to identify regions of unusual conformation in folded RNA. Outliers can be legitimate but less-common backbone conformations, or they may indicate modelling error.
It may take several minutes to complete calculations for large structures such as ribosomes.
Please direct any questions/suggestions to help@emdataresource.org
- Olson, W. K. Configurational statistics of polynucleotide chains. An updated virtual bond model to treat effects of base stacking. Macromolecules 13, 721-728 (1980).
- Wadley, L. M., Keating, K. S., Duarte, C. M. & Pyle, A. M. Evaluating and learning from RNA pseudotorsional space: quantitative validation of a reduced representation for RNA structure. J Mol Biol 372, 942-957, doi (2007).
- Keating, K. S., Humphris, E. L. & Pyle, A. M. A new way to see RNA. Q Rev Biophys 44, 433-466, doi (2011).
- Lu, X. J., Bussemaker, H. J. & Olson, W. K. DSSR: an integrated software tool for dissecting the spatial structure of RNA. Nucleic Acids Res 43, e142, doi (2015).
- Li, S., Olson, W. K., Lu, X. J. Web 3DNA 2.0 for the analysis, visualization, and modeling of 3D nucleic acid structures. Nucleic Acids Research 47, W26-W34 (2019). doi
- Leontis, N. B., & Zirbel, C. L. Nonredundant 3D Structure Datasets for RNA Knowledge Extraction and Benchmarking. In RNA 3D Structure Analysis and Prediction, N. Leontis & E. Westhof (Eds.), (Vol. 27, pp. 281-298). Springer Berlin Heidelberg. doi (2012).
- Richardson, J. S., Schneider, B., Murray, L. W., Kapral, G. J., Immormino, R.M., Headd, J. J., Richardson, D. C., Ham, D., Hershkovits, E., Williams, L. D., Keating, K. S., Pyle, A. M., Micallef, D., Westbrook, J., Berman, H. M. RNA backbone: consensus all-angle conformers and modular string nomenclature (an RNA Ontology Consortium contribution). RNA 14, 465-81, doi (2008).
- Chen, V. B., Arendall III, W. B., Headd, J. J., Keedy, D. A., Immormino, R. M., Kapral, G. J., Murray, L. W., Richardson, J. S., Richardson, D. C., MolProbity: all-atom structure validation for macromolecular crystallography, Acta Cryst D 66, 12-21, doi (2010)
RNA Pseudotorsion Plots for PDB entry 6ndk
Structure of ASLSufA6 A37.5 bound to the 70S A site Deposited 2018-12-13 X-RAY DIFFRACTION resol 3.64 Å
7828 C3'-endo RNA residues with 142 outliers ( 1.81 % ) from Eta-Theta plot
1286 C2'-endo RNA residues with 137 outliers ( 10.65 % ) from Eta-Theta plot
7828 C3'-endo RNA residues with 123 outliers ( 1.57 % ) from Eta'-Theta' plot
1286 C2'-endo RNA residues with 109 outliers ( 8.48 % ) from Eta'-Theta' plot
7828 C3'-endo RNA residues with 96 outliers ( 1.23 % ) from Eta"-Theta" plot
1286 C2'-endo RNA residues with 95 outliers ( 7.39 % ) from Eta"-Theta" plot
List of Outliers
| Model Number | Chain | Residue Type | Residue Identifier | Eta | Theta | Eta' | Theta' | Eta'' | Theta'' | Sugar Pucker | Suiteness |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | QA | G | 247 | 258.0 | 132.0 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | QA | C | 352 | 52.0 | 113.3 | 73.5 | 78.6 | 91.7 | 23.8 | C3'endo | 0.0 |
| 1 | QA | A | 353 | 3.9 | 134.1 | 358.0 | 133.9 | --- | --- | C3'endo | 0.0 |
| 1 | QA | A | 563 | 116.1 | 97.2 | 108.3 | 82.8 | 108.4 | 30.8 | C3'endo | 0.0 |
| 1 | QA | C | 754 | 84.1 | 334.9 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | QA | U | 841 | 43.5 | 296.2 | 107.9 | 293.6 | --- | --- | C3'endo | 0.0 |
| 1 | QA | G | 926 | 40.1 | 52.3 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | QA | G | 1084 | 118.9 | 323.5 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | QA | U | 1136 | 101.8 | 21.0 | 111.2 | 14.0 | 124.4 | 12.7 | C3'endo | 0.0 |
| 1 | QA | U | 1212 | 285.7 | 71.1 | 265.8 | 70.2 | --- | --- | C3'endo | 0.265 |
| 1 | QA | U | 1278 | 238.8 | 30.9 | 238.1 | 43.9 | --- | --- | C3'endo | 0.0 |
| 1 | QA | A | 1447 | 100.1 | 284.3 | 86.3 | 287.0 | --- | --- | C3'endo | 0.0 |
| 1 | QA | A | 1492 | 23.1 | 156.4 | 21.6 | 170.2 | 25.2 | 169.5 | C3'endo | 0.0 |
| 1 | QA | G | 1530 | 102.5 | 125.0 | 136.4 | 138.7 | --- | --- | C3'endo | 0.0 |
| 1 | QV | C | 17 | 134.0 | 358.7 | --- | --- | --- | --- | C3'endo | 0.361 |
| 1 | QV | U | 17A | 26.2 | 284.2 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | QV | U | 47 | 89.7 | 283.8 | 57.3 | 284.8 | --- | --- | C3'endo | 0.0 |
| 1 | RA | C | 34 | 101.4 | 287.4 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | RA | A | 228 | 99.4 | 287.0 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | RA | A | 229 | 252.7 | 67.5 | 281.1 | 75.0 | 287.8 | 91.8 | C3'endo | 0.0 |
| 1 | RA | G | 248 | 100.4 | 310.2 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | RA | U | 273B | 18.5 | 348.8 | 37.1 | 317.5 | --- | --- | C3'endo | 0.0 |
| 1 | RA | A | 443 | 266.6 | 81.4 | 310.0 | 61.5 | 24.0 | 10.4 | C3'endo | 0.238 |
| 1 | RA | A | 480 | 109.5 | 299.1 | --- | --- | --- | --- | C3'endo | 0.028 |
| 1 | RA | U | 504 | 319.4 | 92.9 | 314.8 | 68.7 | 279.4 | 4.3 | C3'endo | 0.0 |
| 1 | RA | A | 572 | 42.3 | 267.0 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | RA | C | 645 | 112.3 | 292.8 | 93.0 | 298.2 | --- | --- | C3'endo | 0.0 |
| 1 | RA | G | 669 | 34.4 | 267.1 | 76.0 | 268.5 | --- | --- | C3'endo | 0.0 |
| 1 | RA | U | 747 | 322.1 | 28.2 | 335.2 | 14.4 | 151.2 | 16.1 | C3'endo | 0.327 |
| 1 | RA | A | 751 | 301.6 | 99.3 | 326.9 | 126.6 | 320.8 | 122.5 | C3'endo | 0.822 |
| 1 | RA | A | 781 | 322.6 | 117.7 | 344.8 | 86.4 | 347.6 | 24.8 | C3'endo | 0.035 |
| 1 | RA | U | 958 | 318.3 | 107.5 | 356.2 | 78.8 | --- | --- | C3'endo | 0.0 |
| 1 | RA | A | 1046 | 357.5 | 9.8 | 348.5 | 11.8 | 64.7 | 37.4 | C3'endo | 0.0 |
| 1 | RA | C | 1064 | 135.3 | 302.8 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | RA | G | 1071 | 76.1 | 127.4 | 118.8 | 123.1 | 122.4 | 99.0 | C3'endo | 0.0 |
| 1 | RA | U | 1082 | 202.9 | 306.1 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | RA | A | 1084 | 315.1 | 270.6 | 288.6 | 296.2 | --- | --- | C3'endo | 0.0 |
| 1 | RA | A | 1086 | 92.2 | 100.5 | 100.6 | 111.2 | 74.4 | 93.0 | C3'endo | 0.0 |
| 1 | RA | A | 1088 | 306.4 | 42.8 | 313.4 | 61.7 | 341.6 | 49.8 | C3'endo | 0.0 |
| 1 | RA | G | 1091 | 114.5 | 70.9 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | RA | A | 1095 | 303.0 | 102.6 | 308.1 | 95.3 | --- | --- | C3'endo | 0.0 |
| 1 | RA | G | 1136 | 12.9 | 162.5 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | RA | U | 1273 | 349.4 | 130.1 | 31.6 | 108.8 | 52.3 | 84.0 | C3'endo | 0.269 |
| 1 | RA | U | 1420 | 64.2 | 283.2 | 72.1 | 271.0 | --- | --- | C3'endo | 0.0 |
| 1 | RA | A | 1583 | 212.4 | 68.8 | 219.3 | 53.3 | --- | --- | C3'endo | 0.0 |
| 1 | RA | C | 1584 | 61.8 | 289.8 | 66.4 | 302.3 | --- | --- | C3'endo | 0.0 |
| 1 | RA | U | 1757 | 327.9 | 351.1 | 333.1 | 332.5 | 15.3 | 354.3 | C3'endo | 0.389 |
| 1 | RA | G | 1816 | 304.1 | 13.6 | 278.8 | 44.2 | 288.9 | 79.5 | C3'endo | 0.0 |
| 1 | RA | A | 1969 | 215.4 | 78.8 | --- | --- | --- | --- | C3'endo | 0.209 |
| 1 | RA | A | 1971 | 14.6 | 335.2 | 5.3 | 326.1 | --- | --- | C3'endo | 0.0 |
| 1 | RA | A | 1981 | 289.4 | 289.9 | 344.1 | 283.6 | --- | --- | C3'endo | 0.017 |
| 1 | RA | A | 2030 | 350.4 | 131.5 | 28.7 | 119.1 | 20.2 | 69.7 | C3'endo | 0.263 |
| 1 | RA | C | 2055 | 235.9 | 46.8 | 254.6 | 58.0 | 302.5 | 127.6 | C3'endo | 0.0 |
| 1 | RA | U | 2130 | 128.4 | 78.4 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | RA | U | 2132 | 317.6 | 33.7 | 315.0 | 38.6 | 2.3 | 55.3 | C3'endo | 0.0 |
| 1 | RA | G | 2206 | 11.3 | 309.4 | 19.7 | 284.7 | --- | --- | C3'endo | 0.0 |
| 1 | RA | G | 2321 | 127.5 | 288.4 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | RA | C | 2347 | 130.3 | 137.2 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | RA | C | 2424 | 91.9 | 335.8 | 73.3 | 324.5 | --- | --- | C3'endo | 0.0 |
| 1 | RA | G | 2428 | 290.6 | 101.2 | 275.4 | 94.3 | --- | --- | C3'endo | 0.0 |
| 1 | RA | G | 2505 | 320.7 | 138.5 | 318.9 | 141.2 | 308.1 | 126.3 | C3'endo | 0.0 |
| 1 | RA | G | 2529 | 34.6 | 63.4 | 37.0 | 19.7 | 26.4 | 345.2 | C3'endo | 0.0 |
| 1 | RA | C | 2573 | 258.3 | 64.9 | 258.7 | 70.1 | --- | --- | C3'endo | 0.01 |
| 1 | RA | A | 2577 | 289.6 | 38.0 | 278.2 | 0.4 | --- | --- | C3'endo | 0.224 |
| 1 | RA | G | 2578 | 45.3 | 130.9 | --- | --- | --- | --- | C3'endo | 0.013 |
| 1 | RA | A | 2712B | 91.4 | 332.3 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | RA | A | 2765 | 96.4 | 269.7 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | RA | G | 2777 | 333.4 | 119.4 | 323.7 | 74.4 | --- | --- | C3'endo | 0.029 |
| 1 | XA | C | 352 | 61.2 | 112.5 | 66.2 | 75.7 | 97.6 | 353.4 | C3'endo | 0.0 |
| 1 | XA | A | 353 | 2.9 | 127.4 | 357.5 | 118.0 | --- | --- | C3'endo | 0.0 |
| 1 | XA | G | 530 | 210.1 | 49.0 | 218.3 | 56.5 | --- | --- | C3'endo | 0.143 |
| 1 | XA | A | 532 | 323.0 | 285.7 | 287.6 | 290.0 | --- | --- | C3'endo | 0.0 |
| 1 | XA | C | 754 | 112.9 | 304.0 | --- | --- | --- | --- | C3'endo | 0.611 |
| 1 | XA | A | 816 | 72.0 | 26.9 | --- | --- | --- | --- | C3'endo | 0.055 |
| 1 | XA | U | 841 | 41.9 | 299.2 | 57.3 | 297.0 | --- | --- | C3'endo | 0.0 |
| 1 | XA | U | 1025 | 241.6 | 118.3 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | XA | C | 1030C | 8.0 | 279.8 | 34.5 | 273.5 | --- | --- | C3'endo | 0.0 |
| 1 | XA | U | 1136 | 85.6 | 15.0 | 95.9 | 331.2 | --- | --- | C3'endo | 0.0 |
| 1 | XA | U | 1257 | 318.0 | 8.1 | 288.2 | 59.0 | 292.6 | 100.0 | C3'endo | 0.0 |
| 1 | XA | U | 1278 | 228.1 | 38.1 | 244.0 | 42.0 | --- | --- | C3'endo | 0.0 |
| 1 | XA | A | 1447 | 57.3 | 28.7 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | XA | C | 1452 | 118.3 | 109.9 | 146.3 | 121.1 | --- | --- | C3'endo | 0.0 |
| 1 | XA | A | 1492 | 43.0 | 118.3 | 15.8 | 147.8 | 5.8 | 192.3 | C3'endo | 0.0 |
| 1 | XA | G | 1530 | 125.5 | 121.0 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | XV | U | 47 | 12.2 | 324.8 | 41.7 | 300.6 | --- | --- | C3'endo | 0.0 |
| 1 | XX | A | 15 | 115.7 | 95.2 | 151.8 | 108.1 | --- | --- | C3'endo | 0.0 |
| 1 | XX | G | 18 | 215.6 | 64.4 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | XY | U | 32 | 356.8 | 341.9 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | YA | C | 34 | 96.7 | 271.6 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | YA | A | 229 | 249.7 | 60.0 | 285.4 | 62.5 | 304.2 | 83.0 | C3'endo | 0.0 |
| 1 | YA | G | 248 | 124.2 | 307.4 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | YA | U | 273B | 26.2 | 323.5 | 32.0 | 311.0 | --- | --- | C3'endo | 0.0 |
| 1 | YA | A | 276 | 130.6 | 84.8 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | YA | A | 443 | 271.4 | 91.3 | 314.3 | 72.0 | 8.3 | 17.9 | C3'endo | 0.624 |
| 1 | YA | A | 480 | 111.9 | 299.8 | --- | --- | --- | --- | C3'endo | 0.059 |
| 1 | YA | U | 504 | 329.2 | 94.0 | 328.2 | 66.1 | 0.9 | 344.2 | C3'endo | 0.222 |
| 1 | YA | C | 645 | 97.8 | 314.5 | 84.8 | 307.4 | --- | --- | C3'endo | 0.0 |
| 1 | YA | U | 747 | 323.0 | 31.2 | 342.6 | 16.6 | 157.3 | 18.2 | C3'endo | 0.0 |
| 1 | YA | U | 958 | 304.8 | 95.3 | 356.9 | 72.6 | --- | --- | C3'endo | 0.26 |
| 1 | YA | G | 974 | 51.9 | 32.9 | 101.5 | 22.0 | --- | --- | C3'endo | 0.0 |
| 1 | YA | A | 1046 | 359.9 | 347.2 | 342.7 | 343.1 | --- | --- | C3'endo | 0.0 |
| 1 | YA | G | 1047 | 208.0 | 64.5 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | YA | C | 1064 | 74.7 | 293.1 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | YA | G | 1068 | 225.4 | 16.0 | 139.0 | 356.5 | --- | --- | C3'endo | 0.0 |
| 1 | YA | A | 1070 | 318.2 | 271.3 | --- | --- | --- | --- | C3'endo | 0.494 |
| 1 | YA | G | 1071 | 133.8 | 89.5 | 144.8 | 118.0 | --- | --- | C3'endo | 0.0 |
| 1 | YA | A | 1084 | 327.9 | 293.2 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | YA | A | 1086 | 137.6 | 76.7 | 127.3 | 100.6 | 102.1 | 106.1 | C3'endo | 0.01 |
| 1 | YA | G | 1087 | 216.4 | 280.7 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | YA | A | 1088 | 291.8 | 44.1 | 316.1 | 54.3 | 10.2 | 29.9 | C3'endo | 0.0 |
| 1 | YA | C | 1092 | 263.6 | 283.1 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | YA | C | 1135 | 84.1 | 260.1 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | YA | G | 1136 | 15.7 | 157.7 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | YA | U | 1273 | 328.1 | 147.4 | 24.6 | 111.6 | 57.7 | 86.9 | C3'endo | 0.0 |
| 1 | YA | C | 1584 | 3.2 | 324.8 | 39.7 | 304.2 | --- | --- | C3'endo | 0.0 |
| 1 | YA | U | 1757 | 329.9 | 354.3 | 337.0 | 335.4 | 14.2 | 344.1 | C3'endo | 0.068 |
| 1 | YA | A | 1900 | 330.9 | 90.6 | 324.6 | 65.9 | 283.8 | 14.2 | C3'endo | 0.01 |
| 1 | YA | C | 1965 | 277.9 | 332.2 | 341.5 | 293.0 | --- | --- | C3'endo | 0.0 |
| 1 | YA | A | 1969 | 216.7 | 87.5 | --- | --- | --- | --- | C3'endo | 0.559 |
| 1 | YA | A | 1971 | 4.6 | 345.4 | 0.9 | 333.0 | --- | --- | C3'endo | 0.0 |
| 1 | YA | A | 1981 | 287.5 | 292.8 | 342.6 | 288.5 | --- | --- | C3'endo | 0.0 |
| 1 | YA | A | 2030 | 354.9 | 111.7 | 30.9 | 104.6 | 21.2 | 77.6 | C3'endo | 0.01 |
| 1 | YA | C | 2055 | 233.0 | 47.1 | 253.9 | 53.9 | 296.2 | 117.2 | C3'endo | 0.0 |
| 1 | YA | U | 2132 | 350.6 | 336.5 | 0.4 | 328.6 | --- | --- | C3'endo | 0.0 |
| 1 | YA | G | 2133 | 215.2 | 109.7 | 227.9 | 136.3 | --- | --- | C3'endo | 0.0 |
| 1 | YA | G | 2206 | 6.8 | 292.8 | 17.2 | 282.4 | --- | --- | C3'endo | 0.0 |
| 1 | YA | C | 2424 | 89.1 | 330.6 | 87.2 | 330.1 | --- | --- | C3'endo | 0.0 |
| 1 | YA | G | 2428 | 287.1 | 103.4 | 272.7 | 98.5 | --- | --- | C3'endo | 0.0 |
| 1 | YA | G | 2502 | 328.8 | 47.8 | 338.4 | 40.9 | 122.5 | 59.8 | C3'endo | 0.0 |
| 1 | YA | G | 2505 | 334.7 | 141.9 | 333.0 | 131.9 | --- | --- | C3'endo | 0.0 |
| 1 | YA | G | 2529 | 46.4 | 55.7 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | YA | A | 2712B | 99.1 | 329.4 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | YA | A | 2765 | 91.9 | 265.4 | --- | --- | --- | --- | C3'endo | 0.0 |
| 1 | QA | A | 397 | --- | --- | 305.1 | 137.0 | --- | --- | C3'endo | 0.0 |
| 1 | QA | A | 665 | --- | --- | 27.8 | 163.9 | 15.9 | 146.9 | C3'endo | 0.0 |
| 1 | QA | C | 1137 | --- | --- | 214.5 | 39.3 | --- | --- | C3'endo | 0.0 |
| 1 | QA | C | 1363A | --- | --- | 125.4 | 359.1 | --- | --- | C3'endo | 0.0 |
| 1 | QV | A | 21 | --- | --- | 256.2 | 140.5 | --- | --- | C3'endo | 0.0 |
| 1 | RA | A | 195 | --- | --- | 212.9 | 330.4 | --- | --- | C3'endo | 0.433 |
| 1 | RA | G | 614C | --- | --- | 285.2 | 154.0 | --- | --- | C3'endo | 0.0 |
| 1 | RA | G | 729 | --- | --- | 325.6 | 2.5 | --- | --- | C3'endo | 0.0 |
| 1 | RA | G | 974 | --- | --- | 107.9 | 13.9 | --- | --- | C3'endo | 0.0 |
| 1 | RA | G | 1068 | --- | --- | 135.8 | 348.9 | --- | --- | C3'endo | 0.0 |
| 1 | RA | C | 1072 | --- | --- | 137.9 | 53.6 | 124.0 | 22.8 | C3'endo | 0.0 |
| 1 | RA | A | 1085 | --- | --- | 258.4 | 151.1 | 294.6 | 91.8 | C3'endo | 0.0 |
| 1 | RA | U | 1255 | --- | --- | 290.6 | 3.8 | --- | --- | C3'endo | 0.0 |
| 1 | RA | A | 2267 | --- | --- | 147.4 | 40.3 | --- | --- | C3'endo | 0.01 |
| 1 | RA | A | 2320 | --- | --- | 114.4 | 80.6 | 176.7 | 68.7 | C3'endo | 0.0 |
| 1 | RA | G | 2645 | --- | --- | 211.3 | 324.5 | 274.1 | 335.9 | C3'endo | 0.0 |
| 1 | RA | C | 2755 | --- | --- | 2.0 | 151.5 | 8.3 | 102.7 | C3'endo | 0.112 |
| 1 | RB | A | 13 | --- | --- | 271.9 | 168.4 | --- | --- | C3'endo | 0.0 |
| 1 | RB | U | 41 | --- | --- | 318.3 | 321.6 | --- | --- | C3'endo | 0.0 |
| 1 | XA | A | 1004 | --- | --- | 265.3 | 275.4 | --- | --- | C3'endo | 0.0 |
| 1 | XA | U | 1281 | --- | --- | 222.0 | 283.7 | --- | --- | C3'endo | 0.0 |
| 1 | XA | C | 1363A | --- | --- | 129.5 | 358.7 | --- | --- | C3'endo | 0.0 |
| 1 | XV | A | 21 | --- | --- | 269.1 | 151.9 | --- | --- | C3'endo | 0.0 |
| 1 | YA | A | 195 | --- | --- | 213.3 | 324.6 | --- | --- | C3'endo | 0.018 |
| 1 | YA | G | 614C | --- | --- | 289.2 | 156.2 | 295.8 | 100.0 | C3'endo | 0.0 |
| 1 | YA | A | 781 | --- | --- | 345.0 | 85.8 | 348.5 | 26.5 | C3'endo | 0.262 |
| 1 | YA | A | 1095 | --- | --- | 327.8 | 339.4 | 317.0 | 336.1 | C3'endo | 0.07 |
| 1 | YA | U | 1779 | --- | --- | 154.4 | 28.0 | 196.7 | 341.8 | C3'endo | 0.069 |
| 1 | YA | A | 1785 | --- | --- | 118.4 | 144.3 | 132.5 | 101.2 | C3'endo | 0.192 |
| 1 | YA | A | 2267 | --- | --- | 148.2 | 41.2 | --- | --- | C3'endo | 0.0 |
| 1 | YA | C | 2573 | --- | --- | 254.7 | 65.9 | --- | --- | C3'endo | 0.0 |
| 1 | YA | A | 2577 | --- | --- | 289.4 | 359.1 | --- | --- | C3'endo | 0.0 |
| 1 | YA | C | 2755 | --- | --- | 356.9 | 149.9 | 354.6 | 109.7 | C3'endo | 0.0 |
| 1 | YA | A | 2781 | --- | --- | 215.0 | 50.6 | --- | --- | C3'endo | 0.309 |
| 1 | YB | U | 41 | --- | --- | 323.8 | 315.8 | 7.6 | 316.5 | C3'endo | 0.0 |
| 1 | QA | G | 6 | --- | --- | --- | --- | 136.9 | 112.9 | C3'endo | 0.332 |
| 1 | QA | U | 368 | --- | --- | --- | --- | 319.2 | 56.3 | C3'endo | 0.036 |
| 1 | QA | A | 722 | --- | --- | --- | --- | 164.0 | 84.7 | C3'endo | 0.126 |
| 1 | QA | C | 1030C | --- | --- | --- | --- | 351.4 | 310.0 | C3'endo | 0.0 |
| 1 | QA | U | 1257 | 326.4 | 346.4 | --- | --- | 293.7 | 55.0 | C3'endo | 0.0 |
| 1 | QA | A | 1493 | --- | --- | --- | --- | 195.7 | 341.5 | C3'endo | 0.0 |
| 1 | QA | G | 1505 | --- | --- | --- | --- | 190.4 | 352.7 | C3'endo | 0.0 |
| 1 | RA | G | 351 | --- | --- | --- | --- | 270.1 | 44.9 | C3'endo | 0.43 |
| 1 | RA | G | 763 | --- | --- | --- | --- | 104.1 | 117.9 | C3'endo | 0.505 |
| 1 | RA | A | 887 | 212.8 | 106.8 | --- | --- | 202.2 | 44.3 | C3'endo | 0.0 |
| 1 | RA | A | 1045 | --- | --- | --- | --- | 152.0 | 347.9 | C3'endo | 0.331 |
| 1 | RA | G | 1056 | --- | --- | --- | --- | 284.7 | 70.2 | C3'endo | 0.042 |
| 1 | RA | A | 1127 | --- | --- | --- | --- | 94.8 | 136.0 | C3'endo | 0.265 |
| 1 | RA | U | 1142A | 304.2 | 46.9 | --- | --- | 182.2 | 20.2 | C3'endo | 0.179 |
| 1 | RA | A | 1274 | --- | --- | --- | --- | 352.6 | 134.1 | C3'endo | 0.12 |
| 1 | RA | C | 1646 | --- | --- | --- | --- | 193.0 | 28.3 | C3'endo | 0.0 |
| 1 | RA | A | 1700 | --- | --- | --- | --- | 343.7 | 298.9 | C3'endo | 0.0 |
| 1 | RA | A | 1785 | --- | --- | --- | --- | 123.7 | 99.4 | C3'endo | 0.424 |
| 1 | RA | G | 2131 | 286.0 | 93.3 | --- | --- | 134.8 | 25.5 | C3'endo | 0.0 |
| 1 | RA | U | 2144 | --- | --- | --- | --- | 295.6 | 25.1 | C3'endo | 0.668 |
| 1 | RA | G | 2429 | --- | --- | --- | --- | 136.5 | 63.9 | C3'endo | 0.0 |
| 1 | RA | U | 2688 | --- | --- | --- | --- | 275.2 | 1.1 | C3'endo | 0.608 |
| 1 | RA | G | 2872 | --- | --- | --- | --- | 88.0 | 137.9 | C3'endo | 0.0 |
| 1 | RA | A | 2883 | --- | --- | --- | --- | 170.6 | 333.9 | C3'endo | 0.0 |
| 1 | XA | G | 6 | --- | --- | --- | --- | 138.8 | 114.0 | C3'endo | 0.0 |
| 1 | XA | U | 368 | 280.8 | 330.1 | --- | --- | 323.4 | 62.2 | C3'endo | 0.0 |
| 1 | XA | A | 665 | --- | --- | --- | --- | 14.3 | 156.9 | C3'endo | 0.0 |
| 1 | XA | G | 1505 | --- | --- | --- | --- | 182.4 | 13.3 | C3'endo | 0.073 |
| 1 | YA | A | 751 | 290.1 | 103.6 | --- | --- | 320.3 | 124.3 | C3'endo | 0.353 |
| 1 | YA | G | 763 | --- | --- | --- | --- | 101.6 | 117.7 | C3'endo | 0.111 |
| 1 | YA | A | 1045 | 233.8 | 101.7 | --- | --- | 135.2 | 354.3 | C3'endo | 0.0 |
| 1 | YA | A | 1069 | --- | --- | --- | --- | 153.5 | 334.0 | C3'endo | 0.0 |
| 1 | YA | C | 1072 | --- | --- | --- | --- | 170.8 | 356.9 | C3'endo | 0.0 |
| 1 | YA | U | 1142A | --- | --- | --- | --- | 264.1 | 30.6 | C3'endo | 0.0 |
| 1 | YA | A | 1274 | --- | --- | --- | --- | 351.4 | 130.3 | C3'endo | 0.0 |
| 1 | YA | A | 1700 | --- | --- | --- | --- | 350.5 | 299.7 | C3'endo | 0.0 |
| 1 | YA | G | 1816 | 309.9 | 18.5 | --- | --- | 286.1 | 87.9 | C3'endo | 0.0 |
| 1 | YA | C | 1967 | --- | --- | --- | --- | 305.0 | 291.1 | C3'endo | 0.0 |
| 1 | YA | G | 2131 | 279.8 | 71.7 | --- | --- | 149.8 | 349.1 | C3'endo | 0.0 |
| 1 | YA | G | 2429 | --- | --- | --- | --- | 133.0 | 113.2 | C3'endo | 0.0 |
| 1 | YA | U | 2438 | --- | --- | --- | --- | 188.6 | 65.3 | C3'endo | 0.587 |
| 1 | YA | A | 2476 | --- | --- | --- | --- | 348.8 | 201.9 | C3'endo | 0.0 |
| 1 | YA | C | 2477 | --- | --- | --- | --- | 183.4 | 51.5 | C3'endo | 0.019 |
| 1 | YA | U | 2688 | --- | --- | --- | --- | 268.8 | 17.6 | C3'endo | 0.208 |
| 1 | YA | G | 2872 | --- | --- | --- | --- | 82.0 | 127.9 | C3'endo | 0.0 |
| 1 | YA | A | 2883 | --- | --- | --- | --- | 170.4 | 346.4 | C3'endo | 0.694 |
| 1 | QA | A | 60 | 296.7 | 174.0 | 25.2 | 136.2 | --- | --- | C2'endo | 0.52 |
| 1 | QA | G | 266 | 320.7 | 134.0 | --- | --- | --- | --- | C2'endo | 0.01 |
| 1 | QA | A | 344 | 96.4 | 355.9 | 99.6 | 323.9 | --- | --- | C2'endo | 0.438 |
| 1 | QA | G | 484 | 93.7 | 125.9 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | QA | A | 815 | 67.7 | 45.4 | 56.9 | 16.1 | --- | --- | C2'endo | 0.253 |
| 1 | QA | U | 820 | 165.8 | 6.8 | --- | --- | --- | --- | C2'endo | 0.588 |
| 1 | QA | U | 960 | 237.5 | 8.5 | 258.9 | 22.2 | --- | --- | C2'endo | 0.01 |
| 1 | QA | A | 968 | 77.4 | 356.0 | 133.8 | 300.9 | --- | --- | C2'endo | 0.0 |
| 1 | QA | A | 974 | 76.4 | 61.5 | 117.6 | 32.3 | --- | --- | C2'endo | 0.0 |
| 1 | QA | A | 975 | 45.8 | 58.5 | 36.1 | 64.5 | 63.7 | 67.0 | C2'endo | 0.0 |
| 1 | QA | U | 992 | 42.5 | 33.9 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | QA | U | 1125 | 147.5 | 266.4 | 155.5 | 196.7 | --- | --- | C2'endo | 0.0 |
| 1 | QA | A | 1157 | 67.7 | 91.6 | 108.0 | 47.6 | --- | --- | C2'endo | 0.053 |
| 1 | QA | U | 1196 | 270.4 | 359.8 | 304.6 | 19.3 | 326.7 | 125.4 | C2'endo | 0.0 |
| 1 | QA | G | 1300 | 273.8 | 49.7 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | QV | G | 18 | 264.7 | 275.7 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | RA | A | 196 | 295.5 | 232.3 | 323.7 | 245.0 | --- | --- | C2'endo | 0.0 |
| 1 | RA | U | 272K | 56.7 | 224.3 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | RA | G | 272M | 147.4 | 279.1 | 177.9 | 198.4 | --- | --- | C2'endo | 0.0 |
| 1 | RA | A | 322 | 164.3 | 342.8 | --- | --- | --- | --- | C2'endo | 0.014 |
| 1 | RA | G | 329 | 24.6 | 256.6 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | RA | A | 330 | 89.0 | 230.9 | 136.1 | 201.7 | --- | --- | C2'endo | 0.0 |
| 1 | RA | G | 386 | 102.2 | 348.5 | 118.1 | 327.0 | --- | --- | C2'endo | 0.0 |
| 1 | RA | A | 457 | 340.5 | 200.8 | 10.8 | 153.3 | 354.9 | 160.2 | C2'endo | 0.0 |
| 1 | RA | G | 481 | 155.6 | 35.2 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | RA | A | 532 | 164.6 | 30.1 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | RA | U | 562 | 299.3 | 153.4 | --- | --- | --- | --- | C2'endo | 0.523 |
| 1 | RA | G | 573 | 245.2 | 199.8 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | RA | C | 574 | 30.6 | 74.7 | 64.7 | 50.9 | --- | --- | C2'endo | 0.089 |
| 1 | RA | A | 614D | 346.0 | 214.5 | --- | --- | --- | --- | C2'endo | 0.305 |
| 1 | RA | A | 627 | 290.5 | 205.6 | 39.8 | 164.7 | --- | --- | C2'endo | 0.0 |
| 1 | RA | A | 896 | 86.1 | 223.7 | 81.3 | 232.1 | --- | --- | C2'endo | 0.0 |
| 1 | RA | C | 975A | 43.1 | 37.6 | 38.9 | 31.1 | 105.6 | 22.2 | C2'endo | 0.0 |
| 1 | RA | G | 1025 | 30.9 | 56.9 | 106.0 | 34.6 | --- | --- | C2'endo | 0.0 |
| 1 | RA | U | 1033 | 51.3 | 225.5 | 23.3 | 199.8 | 345.5 | 145.4 | C2'endo | 0.0 |
| 1 | RA | U | 1065 | 89.0 | 139.6 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | RA | A | 1067 | 65.2 | 39.3 | 57.7 | 79.0 | 39.3 | 89.6 | C2'endo | 0.0 |
| 1 | RA | G | 1252 | 351.0 | 235.5 | 40.1 | 199.9 | --- | --- | C2'endo | 0.0 |
| 1 | RA | A | 1272 | 294.8 | 220.0 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | RA | U | 1453 | 43.2 | 207.7 | --- | --- | --- | --- | C2'endo | 0.168 |
| 1 | RA | G | 1758 | 242.9 | 286.6 | --- | --- | --- | --- | C2'endo | 0.625 |
| 1 | RA | A | 1913 | 78.4 | 75.5 | 74.6 | 78.7 | 79.6 | 137.6 | C2'endo | 0.0 |
| 1 | RA | G | 1930 | 146.4 | 63.3 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | RA | A | 1938 | 19.9 | 237.7 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | RA | U | 1940 | 105.2 | 80.7 | --- | --- | --- | --- | C2'endo | 0.573 |
| 1 | RA | U | 1963 | 49.0 | 224.7 | 57.0 | 202.2 | --- | --- | C2'endo | 0.0 |
| 1 | RA | A | 2031 | 114.7 | 63.0 | 146.3 | 319.9 | --- | --- | C2'endo | 0.0 |
| 1 | RA | G | 2032 | 335.6 | 228.9 | 60.7 | 199.4 | --- | --- | C2'endo | 0.0 |
| 1 | RA | G | 2116 | 3.1 | 249.3 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | RA | U | 2118 | 351.7 | 237.3 | 61.7 | 186.1 | --- | --- | C2'endo | 0.0 |
| 1 | RA | G | 2207 | 40.6 | 73.6 | 167.4 | 323.0 | --- | --- | C2'endo | 0.0 |
| 1 | RA | A | 2208 | 136.3 | 62.3 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | RA | A | 2266 | 81.7 | 50.6 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | RA | G | 2282 | 198.2 | 31.7 | --- | --- | --- | --- | C2'endo | 0.015 |
| 1 | RA | G | 2307 | 72.2 | 87.2 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | RA | G | 2308 | 159.1 | 352.1 | --- | --- | --- | --- | C2'endo | 0.353 |
| 1 | RA | A | 2346 | 339.3 | 45.4 | 350.0 | 353.8 | --- | --- | C2'endo | 0.256 |
| 1 | RA | A | 2425 | 110.8 | 62.7 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | RA | U | 2585 | 95.7 | 139.2 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | RA | A | 2602 | 76.4 | 30.5 | 42.1 | 30.1 | 273.2 | 28.1 | C2'endo | 0.0 |
| 1 | RA | U | 2689 | 93.1 | 72.5 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | RA | U | 2712A | 322.4 | 214.2 | 28.8 | 157.6 | --- | --- | C2'endo | 0.32 |
| 1 | RA | A | 2713 | 49.3 | 248.4 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | RA | U | 2756 | 43.6 | 225.4 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | RA | G | 2867 | 330.1 | 48.0 | --- | --- | --- | --- | C2'endo | 0.644 |
| 1 | RB | C | 12 | 138.0 | 193.7 | --- | --- | --- | --- | C2'endo | 0.121 |
| 1 | RB | C | 109 | 220.0 | 39.6 | --- | --- | --- | --- | C2'endo | 0.062 |
| 1 | XA | A | 51 | 22.8 | 62.4 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | XA | A | 60 | 251.1 | 213.4 | 27.6 | 135.2 | --- | --- | C2'endo | 0.252 |
| 1 | XA | C | 328 | 237.8 | 38.0 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | XA | A | 344 | 58.5 | 6.7 | 86.6 | 324.3 | --- | --- | C2'endo | 0.355 |
| 1 | XA | A | 815 | 73.8 | 18.2 | 62.2 | 357.3 | --- | --- | C2'endo | 0.339 |
| 1 | XA | U | 820 | 161.4 | 21.7 | 216.9 | 346.9 | --- | --- | C2'endo | 0.299 |
| 1 | XA | U | 839 | 42.1 | 54.8 | 87.5 | 330.0 | --- | --- | C2'endo | 0.56 |
| 1 | XA | A | 968 | 74.5 | 349.2 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | XA | A | 974 | 51.1 | 91.1 | 117.8 | 41.1 | 139.8 | 2.4 | C2'endo | 0.0 |
| 1 | XA | A | 975 | 48.8 | 61.3 | 35.7 | 68.4 | 59.2 | 71.7 | C2'endo | 0.0 |
| 1 | XA | G | 1094 | 20.3 | 62.4 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | XA | A | 1285 | 82.6 | 93.1 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | XA | A | 1442C | 135.9 | 156.8 | --- | --- | --- | --- | C2'endo | 0.213 |
| 1 | XV | G | 18 | 317.4 | 234.0 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | XV | G | 53 | 32.8 | 58.8 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | YA | U | 272K | 19.0 | 244.1 | --- | --- | --- | --- | C2'endo | 0.481 |
| 1 | YA | A | 322 | 164.3 | 341.3 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | YA | A | 330 | 70.0 | 240.2 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | YA | G | 386 | 96.4 | 340.7 | 111.2 | 321.9 | --- | --- | C2'endo | 0.0 |
| 1 | YA | A | 454 | 281.0 | 341.1 | --- | --- | --- | --- | C2'endo | 0.01 |
| 1 | YA | C | 456 | 301.6 | 143.5 | --- | --- | --- | --- | C2'endo | 0.093 |
| 1 | YA | G | 481 | 151.7 | 45.3 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | YA | A | 529 | 131.2 | 71.9 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | YA | A | 532 | 155.5 | 27.6 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | YA | G | 573 | 250.0 | 197.2 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | YA | C | 574 | 37.5 | 63.4 | 69.4 | 43.0 | --- | --- | C2'endo | 0.0 |
| 1 | YA | A | 614D | 348.1 | 212.7 | --- | --- | --- | --- | C2'endo | 0.042 |
| 1 | YA | A | 627 | 319.1 | 180.6 | 50.3 | 155.8 | --- | --- | C2'endo | 0.0 |
| 1 | YA | G | 686 | 96.9 | 235.7 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | YA | C | 889 | 152.2 | 274.9 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | YA | A | 896 | 89.0 | 239.5 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | YA | A | 945 | 88.9 | 227.3 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | YA | C | 975A | 52.2 | 26.7 | 31.4 | 33.1 | 112.2 | 25.1 | C2'endo | 0.09 |
| 1 | YA | U | 1012 | 280.7 | 19.3 | 299.8 | 34.6 | --- | --- | C2'endo | 0.0 |
| 1 | YA | G | 1025 | 40.6 | 48.7 | 112.5 | 29.3 | --- | --- | C2'endo | 0.032 |
| 1 | YA | U | 1033 | 45.1 | 224.9 | 21.1 | 197.2 | 347.3 | 136.0 | C2'endo | 0.0 |
| 1 | YA | A | 1126 | 72.1 | 95.1 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | YA | G | 1252 | 351.5 | 240.0 | 41.6 | 207.4 | --- | --- | C2'endo | 0.01 |
| 1 | YA | G | 1416 | 320.1 | 124.3 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | YA | A | 1427 | 107.7 | 77.3 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | YA | C | 1493 | 255.2 | 228.4 | 295.3 | 241.3 | --- | --- | C2'endo | 0.0 |
| 1 | YA | A | 1609 | 31.1 | 201.3 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | YA | G | 1758 | 245.0 | 278.5 | --- | --- | --- | --- | C2'endo | 0.344 |
| 1 | YA | A | 1913 | 95.2 | 52.7 | 82.7 | 76.1 | --- | --- | C2'endo | 0.0 |
| 1 | YA | G | 1930 | 151.7 | 66.4 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | YA | A | 1936 | 240.9 | 43.1 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | YA | U | 1940 | 90.6 | 80.9 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | YA | U | 1963 | 41.2 | 225.1 | 47.0 | 193.7 | 52.7 | 208.9 | C2'endo | 0.0 |
| 1 | YA | A | 2031 | 116.2 | 79.4 | 128.6 | 13.7 | --- | --- | C2'endo | 0.0 |
| 1 | YA | G | 2032 | 292.2 | 271.2 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | YA | A | 2033 | 280.3 | 255.0 | 316.2 | 186.3 | --- | --- | C2'endo | 0.0 |
| 1 | YA | U | 2118 | 23.2 | 245.0 | 68.9 | 199.1 | 48.4 | 209.9 | C2'endo | 0.0 |
| 1 | YA | C | 2145 | 45.7 | 32.4 | 76.5 | 340.9 | --- | --- | C2'endo | 0.124 |
| 1 | YA | C | 2146 | 152.6 | 70.9 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | YA | U | 2172 | 278.6 | 205.2 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | YA | G | 2207 | 137.8 | 2.0 | 181.3 | 331.4 | --- | --- | C2'endo | 0.0 |
| 1 | YA | A | 2266 | 54.6 | 69.7 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | YA | A | 2346 | 351.5 | 23.7 | --- | --- | --- | --- | C2'endo | 0.01 |
| 1 | YA | A | 2425 | 110.5 | 69.7 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | YA | A | 2602 | 66.2 | 36.9 | 39.4 | 30.3 | 285.7 | 31.5 | C2'endo | 0.0 |
| 1 | YA | U | 2689 | 147.8 | 7.2 | --- | --- | --- | --- | C2'endo | 0.0 |
| 1 | YA | A | 2713 | 55.4 | 243.7 | 82.5 | 212.8 | --- | --- | C2'endo | 0.0 |
| 1 | YA | G | 2867 | 336.4 | 55.4 | --- | --- | --- | --- | C2'endo | 0.26 |
| 1 | QA | A | 8 | --- | --- | 284.6 | 238.3 | 276.2 | 270.1 | C2'endo | 0.629 |
| 1 | QA | A | 50 | --- | --- | 73.9 | 85.6 | --- | --- | C2'endo | 0.056 |
| 1 | QA | U | 189G | --- | --- | 324.2 | 248.1 | --- | --- | C2'endo | 0.0 |
| 1 | QA | G | 189H | --- | --- | 119.4 | 324.5 | --- | --- | C2'endo | 0.0 |
| 1 | QA | A | 451 | --- | --- | 80.8 | 110.8 | --- | --- | C2'endo | 0.099 |
| 1 | QA | A | 461 | --- | --- | 72.4 | 195.0 | 32.2 | 163.7 | C2'endo | 0.0 |
| 1 | QA | A | 496 | --- | --- | 157.9 | 210.5 | --- | --- | C2'endo | 0.0 |
| 1 | QA | A | 532 | --- | --- | 289.9 | 238.4 | 301.5 | 275.0 | C2'endo | 0.0 |
| 1 | QA | C | 701 | --- | --- | 181.7 | 8.2 | --- | --- | C2'endo | 0.0 |
| 1 | QA | A | 702 | --- | --- | 73.5 | 324.5 | --- | --- | C2'endo | 0.0 |
| 1 | QA | A | 1201 | --- | --- | 47.4 | 64.7 | 88.8 | 42.6 | C2'endo | 0.235 |
| 1 | QA | A | 1363B | --- | --- | 70.0 | 61.5 | --- | --- | C2'endo | 0.022 |
| 1 | RA | A | 265 | --- | --- | 79.9 | 167.0 | --- | --- | C2'endo | 0.02 |
| 1 | RA | C | 277 | --- | --- | 342.2 | 352.0 | --- | --- | C2'endo | 0.0 |
| 1 | RA | A | 957 | --- | --- | 90.1 | 209.9 | --- | --- | C2'endo | 0.067 |
| 1 | RA | C | 995 | --- | --- | 26.7 | 134.8 | 6.3 | 68.2 | C2'endo | 0.28 |
| 1 | RA | C | 1076 | --- | --- | 81.2 | 194.2 | 40.1 | 230.1 | C2'endo | 0.084 |
| 1 | RA | G | 1325 | --- | --- | 337.9 | 244.9 | --- | --- | C2'endo | 0.139 |
| 1 | RA | C | 1493 | --- | --- | 301.1 | 246.5 | --- | --- | C2'endo | 0.0 |
| 1 | RA | C | 1509A | --- | --- | 335.6 | 320.3 | 291.7 | 350.0 | C2'endo | 0.0 |
| 1 | RA | A | 1722 | --- | --- | 61.7 | 185.2 | 21.7 | 145.9 | C2'endo | 0.0 |
| 1 | RA | A | 2033 | --- | --- | 321.5 | 180.2 | --- | --- | C2'endo | 0.0 |
| 1 | RA | G | 2110 | --- | --- | 217.8 | 349.0 | --- | --- | C2'endo | 0.0 |
| 1 | RA | A | 2119 | --- | --- | 337.5 | 211.1 | --- | --- | C2'endo | 0.0 |
| 1 | RA | C | 2402 | --- | --- | 283.8 | 143.7 | --- | --- | C2'endo | 0.0 |
| 1 | RB | A | 15 | --- | --- | 189.3 | 312.9 | --- | --- | C2'endo | 0.0 |
| 1 | XA | A | 8 | --- | --- | 297.3 | 239.3 | 302.8 | 263.5 | C2'endo | 0.375 |
| 1 | XA | A | 50 | --- | --- | 74.8 | 90.7 | 88.7 | 99.1 | C2'endo | 0.0 |
| 1 | XA | U | 189G | --- | --- | 330.3 | 246.2 | 320.4 | 203.6 | C2'endo | 0.0 |
| 1 | XA | G | 189H | --- | --- | 113.1 | 336.7 | --- | --- | C2'endo | 0.0 |
| 1 | XA | A | 451 | --- | --- | 79.1 | 114.6 | --- | --- | C2'endo | 0.403 |
| 1 | XA | A | 461 | --- | --- | 67.9 | 206.5 | 35.4 | 169.6 | C2'endo | 0.025 |
| 1 | XA | A | 496 | --- | --- | 154.2 | 208.1 | --- | --- | C2'endo | 0.0 |
| 1 | XA | A | 533 | --- | --- | 318.6 | 232.4 | 338.7 | 191.2 | C2'endo | 0.0 |
| 1 | XA | U | 1196 | --- | --- | 307.0 | 19.2 | 321.3 | 122.2 | C2'endo | 0.0 |
| 1 | XA | A | 1201 | --- | --- | 41.2 | 95.3 | --- | --- | C2'endo | 0.0 |
| 1 | XA | A | 1363B | --- | --- | 76.6 | 61.3 | 135.9 | 16.1 | C2'endo | 0.01 |
| 1 | XA | G | 1456 | --- | --- | 304.2 | 320.6 | --- | --- | C2'endo | 0.0 |
| 1 | YA | A | 196 | --- | --- | 325.3 | 242.3 | --- | --- | C2'endo | 0.0 |
| 1 | YA | A | 265 | --- | --- | 77.1 | 155.0 | 42.9 | 180.1 | C2'endo | 0.01 |
| 1 | YA | A | 457 | --- | --- | 8.7 | 152.4 | --- | --- | C2'endo | 0.0 |
| 1 | YA | G | 530 | --- | --- | 151.7 | 184.8 | --- | --- | C2'endo | 0.0 |
| 1 | YA | U | 562 | --- | --- | 305.9 | 128.5 | --- | --- | C2'endo | 0.472 |
| 1 | YA | A | 789 | --- | --- | 270.7 | 267.0 | --- | --- | C2'endo | 0.017 |
| 1 | YA | A | 957 | --- | --- | 82.6 | 212.0 | 45.3 | 168.2 | C2'endo | 0.0 |
| 1 | YA | A | 1067 | --- | --- | 48.7 | 79.5 | 34.7 | 91.5 | C2'endo | 0.0 |
| 1 | YA | C | 1076 | --- | --- | 44.1 | 157.9 | 11.4 | 165.8 | C2'endo | 0.05 |
| 1 | YA | A | 1272 | --- | --- | 265.9 | 217.2 | --- | --- | C2'endo | 0.0 |
| 1 | YA | G | 1325 | --- | --- | 340.0 | 248.8 | --- | --- | C2'endo | 0.0 |
| 1 | YA | C | 1509A | --- | --- | 331.7 | 318.3 | --- | --- | C2'endo | 0.0 |
| 1 | YA | A | 1722 | --- | --- | 78.5 | 192.7 | 26.5 | 134.4 | C2'endo | 0.0 |
| 1 | YA | U | 2712A | --- | --- | 20.5 | 164.1 | --- | --- | C2'endo | 0.052 |
| 1 | QA | A | 51 | 28.9 | 53.4 | --- | --- | 349.7 | 31.4 | C2'endo | 0.0 |
| 1 | QA | U | 65 | --- | --- | --- | --- | 17.6 | 240.5 | C2'endo | 0.459 |
| 1 | QA | G | 129B | --- | --- | --- | --- | 33.1 | 25.8 | C2'endo | 0.0 |
| 1 | QA | A | 533 | --- | --- | --- | --- | 317.0 | 184.7 | C2'endo | 0.0 |
| 1 | QA | U | 561 | --- | --- | --- | --- | 51.6 | 110.1 | C2'endo | 0.292 |
| 1 | QA | U | 1049 | --- | --- | --- | --- | 36.1 | 13.6 | C2'endo | 0.02 |
| 1 | QA | C | 1054 | --- | --- | --- | --- | 62.5 | 48.1 | C2'endo | 0.0 |
| 1 | QA | G | 1094 | --- | --- | --- | --- | 4.2 | 38.3 | C2'endo | 0.0 |
| 1 | QA | A | 1101 | --- | --- | --- | --- | 327.8 | 146.6 | C2'endo | 0.0 |
| 1 | QA | A | 1183 | --- | --- | --- | --- | 346.1 | 196.8 | C2'endo | 0.0 |
| 1 | QV | C | 48 | --- | --- | --- | --- | 343.8 | 235.7 | C2'endo | 0.0 |
| 1 | RA | G | 321 | --- | --- | --- | --- | 337.7 | 291.6 | C2'endo | 0.05 |
| 1 | RA | G | 323 | 90.2 | 55.4 | --- | --- | 153.4 | 25.1 | C2'endo | 0.306 |
| 1 | RA | U | 405 | --- | --- | --- | --- | 16.1 | 9.0 | C2'endo | 0.352 |
| 1 | RA | C | 456 | --- | --- | --- | --- | 56.7 | 110.4 | C2'endo | 0.0 |
| 1 | RA | G | 801 | --- | --- | --- | --- | 6.7 | 195.4 | C2'endo | 0.249 |
| 1 | RA | U | 827 | 346.1 | 50.6 | --- | --- | 329.2 | 25.7 | C2'endo | 0.0 |
| 1 | RA | U | 1205 | --- | --- | --- | --- | 313.9 | 20.3 | C2'endo | 0.04 |
| 1 | RA | U | 1602 | --- | --- | --- | --- | 273.6 | 351.3 | C2'endo | 0.402 |
| 1 | RA | G | 1674 | --- | --- | --- | --- | 343.6 | 95.7 | C2'endo | 0.0 |
| 1 | RA | A | 1780 | --- | --- | --- | --- | 270.0 | 281.0 | C2'endo | 0.0 |
| 1 | RA | A | 1900 | --- | --- | --- | --- | 260.1 | 13.2 | C2'endo | 0.0 |
| 1 | RA | U | 2249 | --- | --- | --- | --- | 300.2 | 249.2 | C2'endo | 0.0 |
| 1 | RA | G | 2318 | --- | --- | --- | --- | 270.1 | 251.5 | C2'endo | 0.567 |
| 1 | RA | G | 2345 | --- | --- | --- | --- | 29.5 | 79.1 | C2'endo | 0.01 |
| 1 | RA | U | 2423 | 353.2 | 55.7 | --- | --- | 339.5 | 68.0 | C2'endo | 0.0 |
| 1 | RA | A | 2439 | --- | --- | --- | --- | 33.8 | 39.6 | C2'endo | 0.0 |
| 1 | RA | U | 2702 | --- | --- | --- | --- | 41.6 | 127.8 | C2'endo | 0.0 |
| 1 | XA | G | 129B | --- | --- | --- | --- | 309.9 | 35.2 | C2'endo | 0.0 |
| 1 | XA | U | 244 | --- | --- | --- | --- | 345.5 | 26.0 | C2'endo | 0.622 |
| 1 | XA | U | 560 | --- | --- | --- | --- | 35.3 | 14.5 | C2'endo | 0.06 |
| 1 | XA | U | 561 | --- | --- | --- | --- | 35.0 | 114.4 | C2'endo | 0.606 |
| 1 | XA | U | 960 | --- | --- | --- | --- | 284.7 | 248.9 | C2'endo | 0.0 |
| 1 | XA | C | 1027 | --- | --- | --- | --- | 268.4 | 269.7 | C2'endo | 0.0 |
| 1 | XA | A | 1157 | --- | --- | --- | --- | 62.9 | 60.5 | C2'endo | 0.129 |
| 1 | XA | A | 1183 | --- | --- | --- | --- | 348.5 | 194.3 | C2'endo | 0.0 |
| 1 | XA | A | 1280 | --- | --- | --- | --- | 316.4 | 340.8 | C2'endo | 0.073 |
| 1 | YA | U | 90 | --- | --- | --- | --- | 64.5 | 140.5 | C2'endo | 0.507 |
| 1 | YA | G | 321 | --- | --- | --- | --- | 345.0 | 293.3 | C2'endo | 0.119 |
| 1 | YA | G | 323 | 90.0 | 70.1 | --- | --- | 160.7 | 30.2 | C2'endo | 0.0 |
| 1 | YA | U | 827 | 6.9 | 36.2 | --- | --- | 336.5 | 27.5 | C2'endo | 0.0 |
| 1 | YA | U | 1205 | --- | --- | --- | --- | 313.8 | 13.0 | C2'endo | 0.0 |
| 1 | YA | A | 1460 | --- | --- | --- | --- | 349.7 | 92.6 | C2'endo | 0.215 |
| 1 | YA | U | 1602 | --- | --- | --- | --- | 285.2 | 346.5 | C2'endo | 0.097 |
| 1 | YA | G | 1674 | --- | --- | --- | --- | 334.8 | 92.9 | C2'endo | 0.0 |
| 1 | YA | A | 1780 | --- | --- | --- | --- | 278.9 | 269.6 | C2'endo | 0.0 |
| 1 | YA | U | 1944 | --- | --- | --- | --- | 18.5 | 191.8 | C2'endo | 0.22 |
| 1 | YA | G | 1964 | --- | --- | --- | --- | 349.5 | 199.5 | C2'endo | 0.01 |
| 1 | YA | C | 2107 | --- | --- | --- | --- | 266.2 | 246.6 | C2'endo | 0.0 |
| 1 | YA | G | 2110 | --- | --- | --- | --- | 260.9 | 3.8 | C2'endo | 0.703 |
| 1 | YA | A | 2119 | --- | --- | --- | --- | 330.2 | 189.3 | C2'endo | 0.0 |
| 1 | YA | U | 2249 | --- | --- | --- | --- | 304.6 | 265.9 | C2'endo | 0.0 |
| 1 | YA | G | 2318 | --- | --- | --- | --- | 275.8 | 245.1 | C2'endo | 0.449 |
| 1 | YA | G | 2345 | --- | --- | --- | --- | 33.8 | 61.2 | C2'endo | 0.0 |
| 1 | YA | U | 2423 | --- | --- | --- | --- | 0.4 | 35.8 | C2'endo | 0.0 |
| 1 | YA | A | 2439 | --- | --- | --- | --- | 27.5 | 32.7 | C2'endo | 0.0 |
| 1 | YA | U | 2585 | 96.2 | 132.5 | --- | --- | 57.7 | 156.7 | C2'endo | 0.0 |
| 1 | YA | G | 2645 | --- | --- | --- | --- | 282.5 | 352.1 | C2'endo | 0.746 |
| 1 | YA | U | 2702 | --- | --- | --- | --- | 50.1 | 121.6 | C2'endo | 0.0 |
| 1 | YB | U | 14 | --- | --- | --- | --- | 335.3 | 307.3 | C2'endo | 0.649 |